Most of us are aware of the fact that, in the year 1927, Charles Lindbergh crossed the Atlantic in a small, single-seat monoplane (named ‘St. Louis), that was run on the power of a light engine. This incident, known in history as “The Spirit Of St. Louis” is what we are probably remembered of, every time we actually hear this phrase. However, the present discourse has nothing to do with that memorable occurrence. Here, we would be trying to get a deeper insight into the researches and studies that are being conducted by the Academic Otolaryngology Clinic, which is established at St. Louis.
The problems related to the tinnitus disease resemble closely those associated with shingles in that, it is highly difficult (almost impossible) to devise an effective treatment plan for this ailment. The number of people who suffer from the tinnitus problems is in excess of 40 million in the continental parts of USA alone, and a vast majority of these patients tend to view the ailment as an agonizing curse. While the affected people are always on the lookout for medicines to cure themselves from this distressing disease, there are no remedies that meet the approval standards of the FDA. Although the performance and suitability of these drugs are considerably hyped up in the papers, on the net, and even via television, they fail badly in the fields of practical application. Thus, the FDA disapproves them.
In this scenario, the clinical research studies that are conducted by the Academic Otolaryngology Clinic at St. Louis are indeed viewed as steps in the right direction. These studies and their results (aimed at coming up with an effective cure for tinnitus problems) are published on a regular basis, so that important facts about the disease can be learnt. We will next turn our attention to a few of these research topics.
One Of The Topics Under The St. Louis Tinnitus Study Involves The Usability Of Gobapentin As A Remedial Measure On Those Affected By Idiopathic or, Subjective Tinnitus. The Research Is Carried Out In The Following Way:
i) What we wish to find out? – Whether subjective, or idiopathic tinnitus cases can be actually cured by the application Tinnitus 911 of Gobapentin, or Neurontin.
ii) What is the method used? – Medical tests, for a duration of eight days. The tests are double-blind in character and are indiscriminate as well.
iii) Where is it held? – Obviously, at the Academic Otolaryngology Clinic, at St. Louis.
iv) What are the issues studied? – Several topics (135, according to count) related to the problems of idiopathic, or subjective tinnitus are closely studied here. Cases where the disease has lasted for at least a period of six months are considered.
v) What is the method? – For the entire duration of 8 weeks, the patients are administered the medicine everyday, at a daily dose of 900-3600 milligrams. Lactose placebo may also be administered to patients.
vi) How are the results measured? – The handicap inventory score that is attached to the tinnitus factor undergoes a change from the starting period (base point) till the end of the 8th week (the end point). These changes are recorded as a measure of the performance of the drug, and
vii) Research findings –
o 11.2 – the measure of change of the actual handicap inventory score associated with the full cohort, when measurements are taken from the day of starting till the culmination of the 8th week.
o 11.3 – the measure of change that was observed in the randomly chosen 56 tinnitus patients, who were administered the Gobapentin drug,
11 is the measure of change in the 56 people who received the placebo treatment.
Concluding Remark From The St. Louis Tinnitus Study – As A Curative Measure For Fighting Problems Of Subjective, or Idiopathic Tinnitus, Gobapentin Is Ineffective, And So Is The Placebo
Let us look into another of the research topics next:
As An Effective Remedy Against Idiopathic, or Subjective Tinnitus, The Value Of Repetitive Transcranial Magnetic Stimulation (in short, rTMS) Technique Is Also Closely Studied By The St. Louis Academic Otolaryngology Clinic. The Study Takes On The Following Mode:
The technique of Neuro-imaging has clearly shown that subjective tinnitus is indeed closely related with hyperactive characters of the sundry cortical parts, the cortices used for hearing as well as the temporal regions located in the middle. A large number of residents of the United States suffer from subjective tinnitus precisely due to these factors.
When the Repetitive Transcranial Magnetic Stimulation (rTMS) technique is applied to those affected by tinnitus ailments, the skull of these people receive a number of magnetic spurs. The cortical parts of the brain, which are basic to these regions, experience the effects of an electro-magnetic field, as a result. The glutaminergic fibers found in the central nervous system of these tinnitus patients are found to display higher levels of inhibitory activity, when treated by the rTMS method, with the stimulations being fixed at a low frequency level (1 Hz). This observation ca, in effect, be taken as a conclusive proof that the rTMS medication technique, though only a recent discovery, has the potential to provide lasting relief to those affected by tinnitus.